Environmental reservoirs for exoS+ and exoU+ strains of Pseudomonas aeruginosa
نویسندگان
چکیده
منابع مشابه
Relative contributions of Pseudomonas aeruginosa ExoU, ExoS, and ExoT to virulence in the lung.
Pseudomonas aeruginosa uses a type III secretion system to promote development of severe disease, particularly in patients with impaired immune defenses. While the biochemical and enzymatic functions of ExoU, ExoS, and ExoT, three effector proteins secreted by this system, are well defined, the relative roles of each protein in the pathogenesis of acute infections is not clearly understood. Sin...
متن کاملidentification of exos, exou genes in pseudomonas aeruginosa
the bacterium pseudomonas aeruginosa is a common cause of infections, and infection with antibiotic-resistant strains can be dangerous. the aim of the present study is to investigate the presence of the exos and exou genes and the formation of biofilms in clinically isolated p.aeruginosa strains. a total of 126 samples were isolated, and p.aeruginosa was identified using biochemical tests. bact...
متن کاملPseudomonas aeruginosa ExoU augments neutrophil transepithelial migration
Excessive neutrophil infiltration of the lungs is a common contributor to immune-related pathology in many pulmonary disease states. In response to pathogenic infection, airway epithelial cells produce hepoxilin A3 (HXA3), initiating neutrophil transepithelial migration. Migrated neutrophils amplify this recruitment by producing a secondary gradient of leukotriene B4 (LTB4). We sought to determ...
متن کاملpresence of exou and exos genes in pseudomonas aeruginosa isolated from urinary tract infections
background: pseudomonas aeruginosa is considered an opportunistic pathogen; several reports indicate that the organism can also cause infections in healthy hosts. four effector proteins have been described in p. aeruginosa: exou, exos, exot, and exoy. these genes that are translated into protein products related to type iii secretion systems. materials and methods: a total of 134 samples were i...
متن کاملAcquisition and evolution of the exoU locus in Pseudomonas aeruginosa.
ExoU is a potent Pseudomonas aeruginosa cytotoxin translocated into host cells by the type III secretion system. A comparison of genomes of various P. aeruginosa strains showed that that the ExoU determinant is found in the same polymorphic region of the chromosome near a tRNA(Lys) gene, suggesting that exoU is a horizontally acquired virulence determinant. We used yeast recombinational cloning...
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ژورنال
عنوان ژورنال: Environmental Microbiology Reports
سال: 2018
ISSN: 1758-2229
DOI: 10.1111/1758-2229.12653